The Neurogenesis Project
Research-backed articles on brain recovery, neuroplasticity, addiction neuroscience, and cognitive optimization from our clinical team.
A 2026 Lancet trial of semaglutide for alcohol use disorder cut heavy drinking by 41 percent. The number needed to treat beat every approved AUD med.
Dr. Drew Edwards · May 12, 2026
Read More →A 20-year follow-up of the ACTIVE study found cognitive speed training cut dementia risk by 25%. The bigger story is what amplifies that effect.
Dr. Sean Orr · May 11, 2026
Read More →A 12-month randomized trial cut brain age by nearly a year with 150 minutes of weekly cardio. The textbook mechanism, BDNF, did not budge. That tells us something important.
Dr. Sean Orr · May 7, 2026
Read More →Three to four daily cups lengthened telomeres and shaved five years off biological age in adults with severe mental illness, a new King's study found.
Dr. Drew Edwards · May 5, 2026
Read More →Addiction hijacks the brain's survival circuitry before willpower ever gets a vote. Treating it without addressing the neurology is like resetting a broken bone without an X-ray.
Dr. Drew Edwards & Dr. Sean Orr · May 2, 2026
Read More →A new University of Minnesota study uses gene therapy to deliver agmatine to the spinal cord and prevents opioid tolerance from developing in the first place.
Dr. Drew Edwards · April 30, 2026
Read More →A 2017 PET-fMRI study tracked dopamine in mothers as they watched their own infants. The same circuit that fires for a baby is the one drugs hijack. That changes how we treat recovery.
Dr. Drew Edwards · April 26, 2026
Read More →Precision neuromedicine integrates pharmacogenomics, blood biomarkers, genetic testing, neurotransmitter metabolites, volumetric MRI, and real-time biometrics. No single test reveals what is actually happening in a living brain.
Dr. Sean Orr · April 24, 2026
Read More →A randomized crossover trial in Scientific Reports found that one month of HEPA filtration improved executive function 12% in adults over 40. Mechanism explained.
Dr. Sean Orr · April 23, 2026
Read More →A WashU study in eNeuro shows a stimulating environment cuts fentanyl use and stress-triggered relapse in rats. What this means for real recovery programs.
Dr. Drew Edwards · April 21, 2026
Read More →The regulatory door on compounded peptides is starting to open. For brain medicine, that is a meaningful shift, and one physicians should be thinking about before patients start asking harder questions.
Dr. Sean Orr · April 20, 2026
Read More →CADASIL is the most common inherited cerebral small vessel disease, and one of the most underdiagnosed. New NOTCH3 data show the spectrum is far broader than textbooks describe.
Dr. Sean Orr · April 17, 2026
Read More →AI exocortex systems build personalized cognitive baselines over years of interaction, detecting subtle decline before any clinical test catches it.
Dr. Sean Orr · April 17, 2026
Read More →A 2026 Science Advances study shows DeltaFosB rewires the hippocampus during chronic cocaine use, driving relapse long after someone stops using.
Dr. Drew Edwards · April 16, 2026
Read More →The first U.S. patient received lab-grown dopamine neurons for Parkinson’s in a Phase IIa trial at Weill Cornell. The era of neural cell replacement is getting closer.
Dr. Sean Orr · April 13, 2026
Read More →New brain age biomarkers and neuroplasticity research are turning cognitive decline from a vague worry into a measurable, treatable problem.
Dr. Sean Orr · April 9, 2026
Read More →A 2026 eLife study maps the brain pathway linking stress to alcohol relapse, showing why rigid recovery patterns are biology, not a failure of willpower.
Dr. Drew Edwards · April 7, 2026
Read More →The Proliv™Rx system just became the first FDA-approved at-home brain stimulation device for treatment-resistant depression. Here's what the clinical data shows.
Dr. Sean Orr · April 3, 2026
Read More →A massive Rutgers-led genetic study confirms addiction risk comes from impulse-control genes, not drug-specific ones, rewriting how we should treat and prevent substance use disorders.
Dr. Drew Edwards · April 2, 2026
Read More →A 58-year-old woman had a normal MRI and a perfect cognitive screening score. Her neurologist said she was fine. Her p-tau217 blood levels told a different story. A new study from Washington University shows this single biomarker can estimate when Alzheimer's symptoms will begin, with a prediction window of fifteen to twenty years.
Dr. Sean Orr · March 31, 2026
Read More →A patient two years into alcohol recovery told me her cravings had gone quiet after starting semaglutide for weight loss. She thought it was coincidental. It wasn't. GLP-1 receptors sit inside the brain's dopamine reward circuit — and a 2024 clinical trial found they reduce alcohol consumption by 40%.
Dr. Drew Edwards · March 28, 2026
Read More →A 58-year-old executive with progressive memory loss gets an MRI—normal. Cognitive testing—borderline. The diagnosis: 'mild cognitive impairment, probably age-related.' That gap between identifying a disease label and understanding the mechanism driving decline is where integrative neurology lives.
Dr. Sean Orr · March 15, 2026
Read More →Eriksson's 1998 discovery that adults produce new hippocampal neurons upended decades of neuroscience dogma. The therapeutic implication was obvious: if we understand what drives neurogenesis, we could drive it therapeutically. That optimism wasn't wrong—but it was incomplete.
Dr. Sean Orr · March 1, 2026
Read More →Standard brain imaging shows you structure. Advanced techniques show you function, connectivity, and metabolic state. When used together—not as separate tests but as an integrated diagnostic system—they reveal what no single test can see.
Dr. Sean Orr · February 1, 2026
Read More →The subgranular zone of the hippocampal dentate gyrus is where adult neurogenesis happens—a few millimeters of tissue where neural stem cells reside and, under the right conditions, give rise to new functional neurons. The biology is precise, the signaling cascades are known, and the clinical applications are finally catching up.
Dr. Sean Orr · December 7, 2025
Read More →Two 52-year-olds can be decades apart neurologically. One has a brain age of 42—hippocampus robust, processing speed fast. The other shows volumetric patterns of someone 65. Advanced imaging reveals that difference and, more importantly, the mechanisms driving it.
Dr. Sean Orr · November 16, 2025
Read More →Every time someone mentions 'brain rejuvenation,' picture a room full of neurologists cringing. The term has been colonized by wellness marketing to mean almost nothing. But the biological processes underlying the concept are real, measurable, and worth taking seriously.
Dr. Sean Orr · October 26, 2025
Read More →'My MRI was normal, so the neurologist said my cognitive problems are psychological.' We hear this constantly. A normal structural MRI rules out tumors and large strokes. It says almost nothing about white matter connectivity, metabolic function, or the subtle changes driving cognitive decline.
Dr. Sean Orr · September 21, 2025
Read More →Addiction rewires the error-detection system. Addicted persons construct elaborate narratives to explain away damage—not because they're liars, but because their brain's error-correction network has gone offline.
Dr. Drew Edwards & Dr. Sean C. Orr · July 23, 2025
Read More →Regenerative neurotherapies occupy a strange space in medicine. The underlying biology is legitimate. The clinical evidence is growing. Yet the marketing is often absurd. Here's what the science actually supports—and what it doesn't.
Dr. Sean Orr · May 25, 2025
Read More →Conventional neurology saves lives in crisis but fails at preventing decline. Integrative neurology combines pharmacology with metabolic optimization, regenerative medicine, and psychology. It
Dr. Sean Orr · May 18, 2025
Read More →Brain failure occurs when neural networks lose the ability to maintain normal function. Understanding this concept is the first step toward recovery.
Dr. Drew Edwards · March 6, 2025
Read More →For much of the twentieth century scientists believed the brain could not repair itself. Modern neuroscience has proven otherwise.
Dr. Drew Edwards · March 6, 2025
Read More →The default mode network and the executive control network suppress each other—when one fires, the other quiets. Peak cognitive performance requires both, coordinated precisely. Most 'brain training' apps ignore this fundamental architecture entirely.
Dr. Sean Orr · March 2, 2025
Read More →The global economy has fundamentally shifted from rewarding physical capacity to rewarding cognitive capacity. Your brain is your primary asset—and most high performers are burning it out.
Dr. Sean C. Orr & Dr. Drew Edwards · September 23, 2020
Read More →When someone you love has addiction, intervention isn't a TV spectacle—it's a structured clinical process designed to work with the addicted brain, not against it.
Dr. Drew Edwards & Dr. Sean C. Orr · September 2, 2020
Read More →Obesity is a metabolic disease, not a willpower problem. The brain's satiety signals misfire through leptin resistance and interoagnosia—and understanding why changes everything about treatment.
Dr. Drew Edwards & Dr. Sean C. Orr · July 3, 2020
Read More →Unforgiveness isn't a moral failing—it's a neurobiological state. The ventral striatum rewards punishment through the same circuitry hijacked by addiction.
Dr. Drew Edwards & Dr. Sean C. Orr · May 26, 2020
Read More →A clinically significant deficiency in dopamine—the brain's salience neurotransmitter. RDS explains addiction, depression, anxiety, ADHD, and hedonic overeating through a single neurobiological mechanism.
Dr. Drew W. Edwards & Dr. Sean C. Orr · April 5, 2020
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